Silodosin has greater affinity for the О± 1A adrenergic receptor than for the О± 1B adrenergic receptor, minimizing the propensity for blood pressure related adverse effects mediated by О± 1B blockade 135 is viagra or cialis better Biochemical fractionation procedures and Western blot analysis confirmed the cytoplasmic localization of the majority of the transfected EBBP data not shown